Mapping Immune Attacks in MS brains
This project aims to uncover how immune cells behave in different regions of the brain in people with multiple sclerosis (MS).

By studying the interaction between proteins and immune cells, the researchers hope to identify what triggers these cells to attack the brain.

The findings could help develop new, more effective treatments to slow or stop the progression of MS, improving the lives of those affected.

 

This project uses a multi-omics approach to map HLA class I/II epitopes and expanded T cell clones in the parenchyma and barriers of the MS brain.

By combining high-resolution immunopeptidomics and TCR sequencing, we aim to identify regional variations in antigen presentation that drive T cell reactivation in MS.

Findings will be validated in preclinical models to assess their encephalitogenic impact. The insights gained could reveal new therapeutic targets to prevent disease progression, offering MS patients more effective, targeted treatment options.