We offer two summaries to allow everyone – patient, loved one, caregiver, or researcher – to understand the key issues of this research, each at their own level.
Science is at its best when it is open to all.
For everyone – Summary in plain language
Could a Common Virus Help Diagnose MS?
Scientists are exploring how the Epstein-Barr virus (EBV), linked to mononucleosis, might play a role in multiple sclerosis (MS).
While EBV is necessary to develop MS, not everyone exposed to the virus gets the disease.
This study investigates whether unique viral markers in the blood and spinal fluid of people with MS could improve diagnosis and treatment, offering new hope for better care.
For specialists – Scientific summary
Exosomal miRNAs and the Epstein-Barr virus: a remote control mechanism in MS?
Recent research showed that contact with the virus causing infectious mononucleosis (Epstein-Barr virus, EBV), is necessary for the development of MS. After infection, the virus remains present in one of the cells of our immune system, the B cell.
The mechanism by which this virus triggers MS in some people is currently unclear. EBV-infected B cells release small vesicles (exosomes) into body fluids such as blood or cerebrospinal fluid.
These exosomes are filled with cellular material, including ‘microRNAs’, small pieces of genetic material, derived from the virus. In this study, we will determine whether the exosomes in the blood and cerebrospinal fluid of people with MS contain more or different EBV microRNAs than people without the disease.
To do this, we will use blood and cerebrospinal fluid that was stored after the diagnostic spinal tap.
Subsequently, we will investigate whether these microRNAs can be used as a biomarker in the diagnosis or treatment of MS.
