Targeting elongation of polyunsaturated fatty acids (PUFAs) to promote CNS repair in MS
There is an unmet medical need for new effective treatments for progressive forms of MS, in which repair of the central nervous system (CNS) is often hampered. There is growing evidence that in immune cells that play an important role in inflammation and repair processes in MS, regulation of lipid metabolism is closely associated to the inflammatory and metabolic phenotype of the cell. In this project, we will study how we can deploy this regulation to steer the cells to promote CNS repair again. For this, we will use innovative lipidomics techniques together with knockdown and overexpression methods to identify new therapeutic targets for the development of improved treatments for progressive MS.
Support given by the Fund Léon and Miriam Velge, managed by the King Baudouin Foundation