Matrix metalloproteinases (MMPs) are enzymes that are implicated in the development of multiple sclerosis. MMPs contribute to excessive activation of the immune system, which leads to damage to the central nervous system and disrupted functioning of nerve cells. Whereas the harmful contributions of MMPs to disease initiation are well known, recent findings also suggest a protective role for MMPs during central nervous system pathology. With this project we aim to identify changes in key biological processes during central nervous system damage in presence and absence of MMPs, by using an innovative protein biomarker platform.