Recent research showed that contact with the virus causing infectious mononucleosis (Epstein-Barr virus, EBV), is necessary for the development of MS. After infection, the virus remains present in one of the cells of our immune system, the B cell. The mechanism by which this virus triggers MS in some people is currently unclear. EBV-infected B cells release small vesicles (exosomes) into body fluids such as blood or cerebrospinal fluid. These exosomes are filled with cellular material, including ‘microRNAs’, small pieces of genetic material, derived from the virus. In this study, we will determine whether the exosomes in the blood and cerebrospinal fluid of people with MS contain more or different EBV microRNAs than people without the disease. To do this, we will use blood and cerebrospinal fluid that was stored after the diagnostic spinal tap. Subsequently, we will investigate whether these microRNAs can be used as a biomarker in the diagnosis or treatment of MS.

Support given by the Fund Jean and Marie Henkens-Lecloux, managed by the King Baudouin Foundation