The recruitment, activation and differentiation of oligodendrocyte precursors, the myelinating cells of the central nervous system, are part of the strategies being tested to treat multiple sclerosis. As this disease progresses, the differentiation capacity of these precursors is inhibited, and this limits the remyelination capacity of the oligodendrocytes. Our project aims to study the role of a molecule,  Elongator, in regulating the differentiation of myelinating cell precursors. We suspect that this molecule exerts a negative influence on oligodendrocyte differentiation. To do this, we have created mice whose oligodendrocytes have been deliberately deprived of this molecule. The proliferation and differentiation properties of these oligodendrocytes will be studied, along with their survival and ability to migrate.