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Prof. Tim Vanmierlo, Prof. Antonio Luchicchi, and Dr. Melissa Schepers

Building Better Models to Study Myelin Repair in MS

Grant

€34,500 / 2 years
UHasselt & Amsterdam UMC

We offer two summaries to allow everyone – patient, loved one, caregiver, or researcher – to understand the key issues of this research, each at their own level. 

Science is at its best when it is open to all.

For everyone – Summary in plain language

Building Better Models to Study Myelin Repair in MS
This study aims to create an innovative human-based model to better understand how myelin is damaged and repaired in multiple sclerosis (MS).

By closely mimicking the human nervous system, this model will help researchers study cell behavior and test potential treatments, paving the way for new therapies that can be applied more effectively in clinical practice.

For specialists – Scientific summary

Unlocking Human Remyelination: iPSC-OPC Injections into Human Brain Slices as an Innovative Remyelination Model
Multiple sclerosis (MS) causes damage to myelin, leading to neurological problems. Current treatments cannot repair this damage.

Traditional animal models and cell cultures fail to replicate the complex function of the human brain. A new model, based on three-dimensional human brain tissue, provides a more accurate way to study remyelination.

By simulating damage and introducing repair cells, scientists can test potential therapies.

This approach has the potential to deliver new insights and accelerate the development of effective treatments for MS.